plantMetabolomicsProject

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
http://metadb.riken.jp/db/plantMetabolomics/0.1/Project/RPMM0033

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

Project

projcet ID
  • RPMM0033
title
  • MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis
description
  • Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data. We provide an open-source software pipeline, which we call MS-DIAL, for DIA-based identification and quantification of small molecules by mass spectral deconvolution. For a reversed-phase LC-MS/MS analysis of nine algal strains, MS-DIAL using an enriched LipidBlast library identified 1,023 lipid compounds, highlighting the chemotaxonomic relationships between the algal strains.
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  • Database Integration Coordination Program by the National Bioscience Database Center (Japan)
  • Grant-in-Aid for Young Scientists (B) (Japan) 25871136
  • US National Science Foundation (NSF)–Japan Science and Technology Agency (JST) Strategic International Collaborative Research Program (SICORP) for Japan–United States metabolomics
  • ST-Core Research for Evolutionary Science and Technology (JST-CREST)
  • NSF (NSF MCB 113944)
  • National Institutes of Health (NIH) (Grants P20 HL113452 and U24 DK097154)
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